Purpose: The toll-like receptor 4 TLR4 signaling pathway is involved in chronic inflammation and insulin resistance, which are associated with obesity and diabetes mellitus. In the present study, a model of high-fat diet HFD feeding of mice was used to investigate the role of TLR4 in overnutrition- and obesity-associated inflammation and infiltration of macrophages and microglia in the retina. Results: The HFD for 6 months showed increased obesity, glucose intolerance, and insulin resistance in mice. Toll-like receptor 4 expression was found in vascular pericytes at the inner retina. The findings suggest that TLR4 is implicated in the pathogenesis of retinal diseases caused by metabolic disorders. Please enable it to take advantage of the complete set of features!
Rivett, Thomas H. Interestingly, immunofluorescence staining showing increased SerpinA3N protein expression can be observed after just one week of high fat diet feeding, consistent with early responses to HFD in the hypothalamus seen in other studies These genes included the cytokine tumour necrosis factor alpha Tnf, interleukin 1 beta Il1b, interleukin 2 Il2, and interleukin 6 Il6, as well as suppressor of cytokine signalling 3 Socs3 from which it was suggested that local inflammation in the hypothalamus resulted in reduced sensitivity to both insulin and leptin signalling from the periphery 2. The authors are responsible for the content and writing of the paper. This is the first report showing that TLR4 signaling plays a role in spontaneous preference for simple sugars and fat.
These genes included the cytokine tumour necrosis factor alpha Tnf, interleukin 1 beta Il1b, interleukin 2 Il2, and interleukin 6 Il6, as well as suppressor of cytokine signalling 3 Socs3 from which it was suggested that local inflammation in the hypothalamus resulted in reduced sensitivity to both insulin and leptin signalling from the periphery 2. Epub Mar In DIO mice visceral pain responses are increased A and similarly, the pain threshold is decreased B compared to lean animals. Interleukin is produced by a specific subset of taste receptor cells and critical for maintaining integrity of mouse taste buds. Cite this article Dalby, M. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer.